Uganda Skin Color

Population descriptive characteristics

Age

there are 273 participants
Table 1: Age distribution
Statistic Age (yrs)
Mean (std) 27.2 (8.4)
std 8.4
min 18.0
max 73.0
Median (range) 25.0 (18.0-73.0)

Sex

Table 2: Sex distribution
Sex Count Percentage
0 Male 156 0.571429
1 Female 117 0.428571

Country of birth

Table 3: Country of birth distribution
Country of Birth Count Percentage
0 Uganda 164 0.600733
1 Sudan (Khartoum) 22 0.080586
2 South Sudan 21 0.076923
3 Somalia 19 0.069597
4 Eritrea 17 0.062271
5 Democratic Republic of Congo 14 0.051282
6 Kenya 5 0.018315
7 Ethiopia 5 0.018315
8 Nigeria (Abuja) 3 0.010989
9 Rwanda 1 0.003663
10 Ghana (Accra) 1 0.003663
11 Chad (N'Djamena) 1 0.003663

Ethnicity

Table 4: Ethnicity distribution
Ethnicity Count Percentage
0 1, Bantu 134 0.490842
1 24, Other 59 0.216117
2 2, Nilotes 28 0.102564
3 3, Nilohamites 19 0.069597
4 20, Somali 19 0.069597
5 5, Arabs 4 0.014652
6 6, Amhara 4 0.014652
7 4, Hamites 2 0.007326
8 13, Igbo 2 0.007326
9 15, Kongo 1 0.003663
10 22, Yoruba 1 0.003663

This is the mean ITA by site and ethnicity

Table 5: Mean ITA by site and ethnicity
Ethnicity 1, Bantu 13, Igbo 15, Kongo 2, Nilotes 20, Somali 22, Yoruba 24, Other 3, Nilohamites 4, Hamites 5, Arabs 6, Amhara
Group                      
Back of Hand (C) -56.08 -22.10 -48.15 -60.40 -47.29 -26.33 -45.81 -59.63 -62.45 -19.93 -22.44
Dorsal - DIP (B) -59.49 -9.37 -50.61 -62.87 -50.62 -60.07 -49.63 -61.91 -70.06 -18.84 -19.55
Fingernail (A) 15.09 21.43 -22.18 9.24 30.61 52.09 27.34 nan nan nan 40.08
Forehead (F) -54.64 -32.03 -60.90 -62.46 -49.78 -45.18 -44.32 -61.92 -54.44 -3.53 -20.32
Inner Upper Arm (E) -38.89 0.18 -44.77 -45.32 -28.68 -13.42 -24.50 -42.56 -46.25 0.23 6.19
Palmar - Opposite DIP (D) 10.11 26.27 2.81 8.67 5.79 33.44 12.42 6.41 21.21 12.65 16.97

ITA and Monk

ITA Range by site

Table 6: ITA range by site
Statistic count mean std min 25% 50% 75% max
Back of Hand (C) 272.0 -52.6 17.8 -80.2 -65.4 -57.3 -43.9 15.3
Dorsal - DIP (B) 272.0 -55.8 18.8 -85.6 -69.2 -60.6 -47.0 53.7
Fingernail (A) 132.0 22.9 26.2 -53.1 8.8 29.8 42.5 58.9
Forehead (F) 272.0 -52.0 19.4 -80.5 -67.4 -56.7 -39.9 16.7
Inner Upper Arm (E) 272.0 -34.5 20.2 -70.2 -49.2 -36.9 -22.8 31.3
Palmar - Opposite DIP (D) 272.0 10.3 13.2 -35.1 2.4 11.0 20.3 42.2

Monk vs ITA

Mean forehead ITA by Monk measurement

Table 7: Mean forehead ITA by Monk measurement, Uganda group only
  mean median std IQR
Monk - FH (F)        
B 4.21 5.76 13.30 13.23
D -19.43 -20.97 13.34 16.86
E -24.63 -25.18 11.90 12.35
F -41.74 -39.69 7.74 11.14
G -50.78 -49.43 9.01 13.08
H -62.21 -63.86 8.91 11.21
I -69.24 -69.16 6.57 6.52
J -74.17 -74.62 4.67 7.29

How does this compare to the San Francisco data?

Table 8: Mean forehead ITA by Monk measurement, Uganda and San Francisco cohorts
  count median IQR
Source SF Uganda SF Uganda SF Uganda
MST Forehead            
A 4.00 nan 50.08 nan 12.21 nan
B 33.00 3.00 43.07 5.76 9.94 13.23
C 34.00 nan 41.29 nan 11.93 nan
D 115.00 12.00 33.47 -20.97 11.37 16.86
E 190.00 37.00 24.72 -25.18 12.42 12.35
F 116.00 20.00 12.54 -39.69 15.15 11.14
G 77.00 51.00 -13.02 -49.43 17.71 13.08
H 90.00 93.00 -44.49 -63.86 25.84 11.21
I 16.00 31.00 -58.09 -69.16 20.37 6.52
J 2.00 17.00 -72.61 -74.62 0.70 7.29

Monk and Site of measurement

Banana curve

(a) Forehead ITA measurements
(b) Forehead ITA measurements at all sites
Figure 1: Banana curve for forehead ITA measurements
(a) Forehead ITA measurements (Uganda)
(b) Forehead ITA measurements (SF)
Figure 2: Banana curve with proposed cutoffs

Colorimeters Comparison

Paired Wilcoxon Signed-Rank Test


Wilcoxon Signed-Rank Test Results for Dorsal - DIP (B)
  AMT510 ITA: W-statistic = 3085.0000, p-value = < 0.001
  RM200QC ITA: W-statistic = 6172.0000, p-value = < 0.001
  ColorReader Pro ITA: W-statistic = 8902.0000, p-value = < 0.001

Wilcoxon Signed-Rank Test Results for Palmar - Opposite DIP (D)
  AMT510 ITA: W-statistic = 7.0000, p-value = < 0.001
  RM200QC ITA: W-statistic = 4337.0000, p-value = < 0.001
  ColorReader Pro ITA: W-statistic = 89.0000, p-value = < 0.001

Wilcoxon Signed-Rank Test Results for Back of Hand (C)
  AMT510 ITA: W-statistic = 4185.0000, p-value = < 0.001
  RM200QC ITA: W-statistic = 13921.0000, p-value = < 0.001
  ColorReader Pro ITA: W-statistic = 4764.0000, p-value = < 0.001

Wilcoxon Signed-Rank Test Results for Inner Upper Arm (E)
  AMT510 ITA: W-statistic = 907.0000, p-value = < 0.001
  RM200QC ITA: W-statistic = 15814.0000, p-value = 0.0665
  ColorReader Pro ITA: W-statistic = 803.0000, p-value = < 0.001

Wilcoxon Signed-Rank Test Results for Forehead (F)
  AMT510 ITA: W-statistic = 5694.0000, p-value = < 0.001
  RM200QC ITA: W-statistic = 12721.0000, p-value = < 0.001
  ColorReader Pro ITA: W-statistic = 10139.0000, p-value = < 0.001

Wilcoxon Signed-Rank Test Results for Fingernail (A)
  AMT510 ITA: W-statistic = 506.0000, p-value = < 0.001
  RM200QC ITA: W-statistic = 2580.0000, p-value = < 0.001
  ColorReader Pro ITA: W-statistic = 3571.0000, p-value = 0.8772

Pairplot

Pairplot for Back of Hand (C)

Pairplot for Dorsal - DIP (B)

Pairplot for Fingernail (A)

Pairplot for Forehead (F)

Pairplot for Inner Upper Arm (E)

Pairplot for Palmar - Opposite DIP (D)

Bland Altman Plot

Bland Altman plot for Back of Hand (C)

Bland Altman plot for Dorsal - DIP (B)

Bland Altman plot for Fingernail (A)

Bland Altman plot for Forehead (F)

Bland Altman plot for Inner Upper Arm (E)

Bland Altman plot for Palmar - Opposite DIP (D)

Paired Wilcoxon Test

P-values were <0.001 for most of anatomical sites across the colorimeters, indicating that the ITA values measured by each colorimeter differ significantly from those measured by the KM. Although we see a p-value of 0.8772 at the Fingernail site for the ColorReader Pro, the Spearman’s rho and the Bland Altman analyses suggest that we need to be cautious with the interpretation as lack of significance may due to high variability across the measurements, rather than true agreement between devices.

Pairplot and Spearman’s rho

Measurements at the Inner Upper Arm, Forehead, and Back of Hand sites show high Spearman’s rho values (all > 0.90), indicating strong monotonic relationships between the ITA values measured by the colorimeters and the KM. Specifically, the Inner Upper Arm site exhibited the strongest correlations, with Spearman’s rho values exceeding 0.97 across all three colorimeters, suggesting a strong association of ITA values between the colorimeters and the KM. In contrast, for measurements taken at the Fingernail site, Spearman’s rho values were consistently below 0.7 across all colorimeters. This suggests a large inconsistency in measurement between the colorimeters and the KM at the Fingernail site.

Bland Altman plot

Across most sites, colorimeters systematically underestimated ITA values compared to KM, with mean differences ranging from about 0.5 to 23.7 units. If looking at the 95% limits of agreement (LOA), the Fingernail site shows very wide LOAs, with the LOAs span exceeding 80 degrees. This suggests that, although the mean difference may not be large (mean difference = 0.44 for ColorReader Pro), individual measurements can differ substantially, making the colorimeter and KM measurements at the Fingernail site non-interchangeable.